Brain white-matter hyperintensities and treatment outcome in major depressive disorder
نویسندگان
چکیده
منابع مشابه
Brain white-matter hyperintensities and treatment outcome in major depressive disorder.
BACKGROUND An increased incidence of brain white-matter hyperintensities has been described in major depressive disorder, butthe impact of such hyperintensities on treatment outcome is still controversial. AIMS To investigate the relationship of brain white-matter hyperintensities with cardiovascular risk factors and with treatment outcome in younger people with major depressive disorder. M...
متن کاملWhite matter abnormalities and illness severity in major depressive disorder.
BACKGROUND White matter abnormalities have been implicated in the aetiology of major depressive disorder; however, the relationship between the severity of symptoms and white matter integrity is currently unclear. AIMS To investigate white matter integrity in people with major depression and healthy controls, and to assess its relationship with depressive symptom severity. METHOD Diffusion ...
متن کاملElevated DNA Oxidation and DNA Repair Enzyme Expression in Brain White Matter in Major Depressive Disorder
Background Pathology of white matter in brains of patients with major depressive disorder (MDD) is well-documented, but the cellular and molecular basis of this pathology are poorly understood. Methods Levels of DNA oxidation and gene expression of DNA damage repair enzymes were measured in Brodmann area 10 (BA10) and/or amygdala (uncinate fasciculus) white matter tissue from brains of MDD (n...
متن کاملWhite matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder.
OBJECTIVE The aim of this study was to explore the microstructural integrity of whole-brain white matter by diffusion tensor imaging in first-episode, treatment-naive young adults with major depressive disorder. METHOD Diffusion tensor imaging scans were obtained from 14 first-episode, treatment-naive young adult patients with major depressive disorder and 14 healthy comparison subjects. A vo...
متن کاملWhite matter integrity deficit in treatment-naïve adult patients with major depressive disorder.
OBJECTIVES The fronto-limbic system plays critical roles in cognitive functions, including emotion. This is supported by recent reports in the studies of major depressive disorder using diffusion tensor imaging of the brain. This study examined white matter integrity and correlations to cognitive function in treatment-naive adult patients with major depressive disorder. METHODS Fractional ani...
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ژورنال
عنوان ژورنال: British Journal of Psychiatry
سال: 2006
ISSN: 0007-1250,1472-1465
DOI: 10.1192/bjp.188.2.180